二种方法：

一、代码实现

1.引入相关api

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[DllImport("gdi32.dll", EntryPoint = "GetDeviceCaps", SetLastError = true)]
private static extern int GetDeviceCaps(IntPtr hdc, int nIndex);

// http://pinvoke.net/default.aspx/gdi32/GetDeviceCaps.html
enum DeviceCap
{
    VERTRES = 10,
    PHYSICALWIDTH = 110,
    SCALINGFACTORX = 114,
    DESKTOPVERTRES = 117,
}

2.获取屏缩放因子

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private static double GetScreenScalingFactor()
{
	var g = Graphics.FromHwnd(IntPtr.Zero);
	IntPtr desktop = g.GetHdc();
	var physicalScreenHeight = GetDeviceCaps(desktop, (int)DeviceCap.DESKTOPVERTRES);
	
	var screenScalingFactor =
	(double)physicalScreenHeight / Screen.PrimaryScreen.Bounds.Height;
	
	return screenScalingFactor;
}

3.获取屏幕分辨率

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public static int[] GetScreenResolution()
{
    double d = GetScreenScalingFactor();
    // 获取屏幕分辨率
    int screenWidth = Convert.ToInt32(Screen.PrimaryScreen.Bounds.Width * d);
    int screenHeight = Convert.ToInt32(Screen.PrimaryScreen.Bounds.Height * d);
    return new int[] { screenWidth, screenHeight };
}

4.获取屏幕图像

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public static void GetScreenPicFile()
{
    // 获取屏幕分辨率
    int[] screenResolution = PicLibrary.PicClass.GetScreenResolution();
    int screenWidth = screenResolution[0];
    int screenHeight = screenResolution[1];
    // 创建Bitmap对象来保存屏幕截图
    using (Bitmap screenshot = new Bitmap(screenWidth, screenHeight))
    {
        // 创建Graphics对象来绘制屏幕截图
        using (Graphics graphics = Graphics.FromImage(screenshot))
          {
            // 将屏幕内容复制到Graphics对象中
            graphics.CopyFromScreen(0, 0, 0, 0, new Size(screenWidth, screenHeight));
        }
        // 保存屏幕图像为文件
        string filePath = Environment.GetFolderPath(Environment.SpecialFolder.Desktop) + "\\screenshot.png";
    }
    screenshot.Save(filePath);
}

2.配置实现。
https://www.chinesehongker.com/portal.php?mod=view&aid=3248